RAF Typhoon FGR4s have operated alongside France's air force in a joint strike targeting an underground arms cache in Syrian territory operated by the Islamic State group (IS), per a report from the UK's MoD.
The site, located using reconnaissance, was assessed as storing arms and explosives, the announcement noted, and was located in mountains just to the north of Palmyra in Syria's central region.
"Our fighter planes employed laser-guided Paveway IV weapons to strike a series of approach shafts providing entry to the depot... early reports suggest the target was engaged successfully," the MoD said.
There was no sign of any civilian casualties in the attack conducted Saturday night and all the aircraft returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
Daesh - also known as the so-called Islamic State - established militant control over parts of Syria and Iraq until 2019.
"This action underscores our UK leadership, and commitment to operate in unison with our partners, to stamp out any re-emergence of Daesh and their harmful and extremist ideologies in the region," UK Defence Secretary John Healey said.
UK warplanes have carried out patrols over Syrian airspace to "deter any attempted comeback" of IS following its routing at the battle of Baghuz in the year 2019, the ministry said.
"I must thank the personnel of British forces involved in this strike for their skill and their bravery," he added. "They were part of numerous British personnel deployed over Christmas and New Year. This operation, to eliminate militants who endanger our way of life, shows how our armed forces are always on standby, all year round, protecting the UK domestically and powerful internationally."
In December, the American forces conducted what it called a "large-scale strike" targeting Islamic State objectives in Syria, after an ambush claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The UN estimates Daesh still has roughly 5-7 thousand fighters in both countries.
